生物活性物的生物制造：现状、挑战和发展趋势

Biomanufacturing of bioactive compounds: current situation, challenges, and future perspectives

摘要:

生物活性物的生物制造是指利用包括细胞、微生物和酶在内的生物系统生产具有生物活性的天然或合成分子的过程。这些分子可用于制药、化妆品、农业和食品工业等领域，对提高生命质量、延长生命长度具有重要意义。在合成生物学和自动化等技术的推动下，生物制造领域迅速发展，为创造新产品和替代传统产品提供了绿色可持续的生产模式，为生物经济的增长、创新作出了重要贡献。本文结合生物活性物研发及生产情况，简要梳理并分析了国内外生物活性物的现有市场和未来发展。生物制造作为一种绿色、可持续的生产方式，将在生物经济发展中持续发挥重要作用。

Abstract:

Biomanufacturing uses biological systems, including cells, microorganisms, and enzymes, to produce natural or synthetic molecules with biological activities for use in various industries, such as pharmaceuticals, cosmetics, and agriculture. These bioactive compounds are expected to play important roles in improving the quality of life and prolonging its length. Fortunately, recent advances in synthetic biology and automation technologies have accelerated the development of biomanufacturing, enabling us to create new products and replace conventional methods in a more sustainable manner. As of now, the role of biomanufacturing in the growth and innovation of bioeconomy is steadily increasing, and this techbology becomes a prevalent technology in global markets. To gain a comprehensive understanding of this field, this article presents a retrospective review of Bloomage Biotechnology’s Research and Development and briefly reviews the developments of biomanufacturing and offers insights into the futre prospects. In conclusion, biomanufacturing will continue to be an important, environmentally friendly, and sustainable production mode in the ongoing development of bioeconomy.