Abstract:Under the background of developing new engineering disciplines, teaching reform is a key strategy applied by higher education institutions to develop new engineering professionals and accomplish the mission of cultivating morality and nurturing talents. As a foundational course for majors of life sciences and food sciences, “Principles of Fermentation Engineering” has a strong scientific, practical, and historical focus. It serves as an excellent resource for changing the way that college students are taught professional courses. To examine the reform and practical route of specialized course teaching combined with innovation and entrepreneurship fostering under the integration production, education, and research, this article takes the teaching of “Principles of Fermentation Engineering” for undergraduates majoring in food science and engineering at Hebei Agricultural University as an example. A new teaching paradigm integrating production, education, and research is developed considering a variety of factors, including instructional content, teaching methods, and evaluation approaches. This paradigm is result-oriented, replaces examination with competition, and promotes learning by research. It achieves the integration of specialized course teaching and innovation and entrepreneurship fostering and lays a foundation for the teaching reform and the development of professional talents in the context of developing new engineering disciplines.