Abstract:The major science and technology infrastructure in the field of life science is an indispensable and important content in the large-science facility landscape. It encompasses cutting-edge, strategic, and fundamental aspects. This field differs from traditional facilities such as particle physics, astronomy and nuclear energy. Moreover, it represents a relatively underdeveloped area in China’s facility landscape. Unique characteristics are observed in terms of capital investment, physical form, facility lifespan, digitization degree, organizational structure, project risk, and development effect when compared to traditional facilities. Despite its importance, challenges persist in project establishment, investment, management, and construction. Therefore, it is necessary to strengthen the condensing mechanism for addressing major scientific issues in the life science field, improve the strategic investment layout, facilitate the localization of technical equipment based on original scientific ideas, and strengthen the differentiated management capacity of life science facilities.