基于生产工艺管理的生物工程综合性实验设计

Engineering and process management-based design of Comprehensive Biotechnology Experiment course

摘要:

生物工程综合性实验课程以企业人才需求为导向，解决实际生产过程中的复杂工程问题为教学目标，利用两步酶转化法制备l-天冬氨酸和l-丙氨酸的工艺路线，结合生物工程专业生产工艺管理的特点，借鉴生产企业现场管理经验，实施四班三运转的实验运行方式。成绩考核加入交接班总结评价与团队协作评价，该课程设置了包含多门专业核心课程原理、方法与实验技术和企业生产管理模式的新型生物工程综合性实验教学内容，并通过教学实践，持续改进，形成完整的实验教学过程与考核机制。生物工程综合性实验课程取得了良好的教学效果，促进了生物工程专业实验教学的发展。

Abstract:

Based on the demand of enterprise talents and the characteristics of manufacturing process management in biotechnology, in order to make the students acquire the ability to solve complex engineering problems in the production process, we developed a "Comprehensive Biotechnology Experiment" course, where two-step enzymatic production of l-aspartate and l-alanine were the key processes. In this course, we drew lessons from the site management of the production enterprise, performed the experimental operation mode of four shifts and three operations. The content of this course includes principles, methods and experimental techniques of several core curricula and the site management mode of enterprises. As to the evaluation, the summary of the experimental staff's handover records and the content of teamwork were examined and scored. Through teaching practice and continuous improvement, we developed a complete experimental teaching process and assessment mechanism. Overall, the Comprehensive Biotechnology Experiment course achieved good teaching effect, which may serve as a reference to promote the development of experimental teaching of biotechnology.