糖鞘脂介导细胞凋亡及其在肿瘤治疗中的研究进展

Glycosphingolipid-mediated apoptosis and tumor therapy: a review

摘要:

糖鞘脂（glycosphingolipids，GSLs）广泛存在于各种生物细胞膜的磷脂双分子层中，在维持细胞膜稳定性、调节包括粘附、增殖、凋亡和识别等多种细胞过程方面发挥着重要作用，并参与细胞多种生命活动。除此之外，GSLs与细胞凋亡过程密切相关，肿瘤相关GSLs有望作为恶性肿瘤的诊断标志物和免疫治疗靶点，这些发现对研究细胞凋亡及肿瘤治疗的新方向具有重要意义。因此，本文综述了GSLs介导细胞凋亡及其影响肿瘤细胞发生、发展和转移的最新研究进展，并讨论了GSLs代谢途径及其在肿瘤治疗中的研究现状，以及基于GSLs的靶向治疗策略的发展前景。

Abstract:

Glycosphingolipids (GSLs) are widely distributed in the phospholipid bilayer of various cell membranes, which play an important role in maintaining cell membrane stability, and regulate various cellular processes including adhesion, proliferation, apoptosis and recognition, as well as participate in various cellular activities. In addition, GSLs are not only involved in the process of apoptosis, but also regulate multiple signals in tumorigenesis and tumor development. The tumor-associated GSLs are expected to be used as diagnostic markers and immunotherapeutic targets for malignant tumors. These findings have important implications for the study of apoptosis and provide the new direction of tumor therapy. This review summarized the latest research progress of GSLs-mediated apoptosis and its effect on the genesis, development and metastasis of tumor cells. Moreover, we discussed the metabolic pathway of GSLs-mediated apoptosis and its application in tumor therapy, as well as the development prospect of targeted therapy strategies based on GSLs.