多组学技术及其在生命科学研究中应用概述

Multi-omics technology and its applications to life sciences: a review

摘要:

随着新一代测序技术、高分辨质谱技术、多组学整合分析方法及数据库的发展，组学技术正从传统的单一组学向多组学技术发展。以多组学驱动的系统生物学研究将带来生命科学研究的新范式。本文简要概述了基因组学、表观基因组学、转录组学，蛋白质组学及代谢组学的进展，重点介绍多组学技术平台的组成和功能，多组学技术的应用现状及在合成生物学及生物医学等领域的应用前景。

Abstract:

With technological advances in high-throughput sequencing, high resolution mass-spectrometry, and multi-omics data integrative tools and data repositories, the omics research in life sciences are evolving from single-omics strategy to multi-omics strategy. The research of system biology driven by multi-omics will bring a new paradigm in life sciences. This paper briefly summarizes the development of genomics, epigenomics, transcriptomics, proteomics and metabolomics, highlights the composition and function of multi-omics platforms as well as the applications of multi-omics technology, and prospects future applications of multi-omics in synthetic biology and biomedicine.