四吡咯化合物生物合成研究进展

Advances in the biosynthesis of tetrapyrrole compounds

摘要:

四吡咯化合物是存在于生物体中一类具有重要功能的化合物,已经广泛应用于农业、食品和医药等领域。由于化学合成法的烦琐流程和高昂成本以及动植物提取法存在品质不均一等缺点,大幅度限制了其工业化生产与相关应用。近年来,合成生物学的快速发展为微生物利用可再生生物质资源高效合成四吡咯化合物提供了新的技术手段。针对四吡咯化合物生物合成的最新研究进展,文中综述了利用生物法合成这类化合物的各种策略,探讨了提高其生物合成效率的方法,并展望了这类化合物的研究方向,以期为四吡咯化合物的生物合成提供参考。

Abstract:

Tetrapyrrole compounds are a class of compounds with important functions.They exist in living organisms and have been widely used in agriculture,food,medicine,and other fields.The cumbersome process and high cost of chemical synthesis,as well as the shortcomings of unstable quality of animal and plant extraction methods,greatly hampered the industrial production and applications of tetrapyrrole compounds.In recent years,the rapid development of synthetic biology has provided new tools for microorganisms to efficiently synthesize tetrapyrrole compounds from renewable biomass resources.This article summarizes various strategies for the biosynthesis of tetrapyrrole compounds,discusses methods to improve its biosynthesis efficiency and future prospects,with the aim to facilitate the research on biosynthesis of tetrapyrrole compounds.