计算机辅助筛选核酸适配体技术

Computer-aided aptamers screening technologies: a review

摘要:

计算机信息技术已经渗透到我们生活的方方面面，不仅可以辅助药物的筛选，也能够模拟药物的作用。目前已有研究使用计算机辅助技术筛选适配体，对筛选效率的提升和筛选高亲和力的适配体有着重要的指导作用。文中将主要对计算机通过序列评估、结构分析、分子对接3个方面辅助适配体筛选的方法进行综述。

Abstract:

The computer information technology that has penetrated into every aspect of our lives, can not only assist the screening of drugs, but also simulate the effect of drugs. At present, computer-aided technologies have been used to screen aptamers, which play an important role in improving the screening efficiency and screening high affinity binding aptamers. This review summarized the screening methods of aptamers through computer-aided sequence evaluation, structural analysis and molecular docking.