肺部菌群和肠道菌群及其互作与肺癌发生发展的相关性研究进展

Lung and gut microbiota and their interaction with the carcinogenesis and development of lung cancer: a review

摘要:

肺部菌群及肠道菌群与肺癌密切相关，研究发现与健康人群相比肺癌患者的肺部及肠道菌群发生失调，即菌群组成结构发生显著改变。随着“肠-肺轴”概念的提出，肺部及肠道菌群在人体内的紧密联系越发受到重视，因此关于肺部及肠道菌群的研究对于阐明肺癌的发生发展机制有重要的指引作用。文中综述了肺癌患者肺部及肠道菌群的组成特点及可能的互作机制，强调了肠-肺轴中免疫系统的重要性，最后总结了肺部及肠道菌群对肺癌临床治疗的影响，并对肺部及肠道菌群可作为肺癌早期诊断与治疗的新颖靶点进行了展望。

Abstract:

Lung microbiota and gut microbiota are closely related to lung cancer. Studies have shown that the dysbiosis, i.e., the significantly altered composition and structure of gut and lung microbiota, usually occurs in patients with lung cancer. With the introduction of “Gut-Lung Axis”, an increasing attention has been paid to the close relationship between the lung and gut microbiota in human body. A deeper insight into this relationship would facilitate understanding the mechanisms behind the carcinogenesis and development of lung cancer. This article summarizes the composition of lung and gut microbiota in patients with lung cancer and the possible interaction mechanisms, highlighting the importance of the immune system in the Gut-Lung Axis. The effects of lung and gut microbiota on the clinical treatment of lung cancer were summarized, based on which the authors propose that the lung and gut microbiota can be used as novel targets for early diagnosis and treatment of lung cancer.