微生物-肠-脑轴与神经系统疾病的研究进展

Microbe-gut-brain axis and neurological disorders: a review

摘要:

肠道微生物对神经系统疾病 (如帕金森病、抑郁症和阿尔兹海默症等) 的治疗具有辅助治疗的作用。其主要通过神经通路、免疫通路以及微生物代谢物等途径在肠-脑轴的作用下影响大脑功能和宿主行为。因此，文中结合国内外的研究进展，就微生物-肠-脑轴在神经系统疾病中的主要作用进行探讨，以期为神经退行性疾病的治疗提供新思路。

Abstract:

Intestinal microbes have an adjuvant therapeutic effect on neurological disorders (such as Parkinson’s, depression, and Alzheimer’s disease). It affects brain function and host behavior through the neural pathways, the immune pathways and the microbial metabolites, the so-called gut-brain axis. This article summarizes the recent advances in the role of the microbe-gut-brain axis in neurological disorders, in order to provide new ideas for the treatment of neurodegenerative diseases.