SWI/SNF染色质重塑复合物亚基Baf60a调控能量代谢稳态的研究进展

Progress in the regulation of energy metabolic homeostasis by the SWI/SNF complex subunit Baf60a

摘要:

代谢综合征是一种全球性的慢性流行病，其发病机理由遗传与环境等因素共同决定。表观遗传修饰是在基因的核苷酸序列不发生改变的情况下，通过可遗传的变化调控基因表达。近年来研究发现，表观遗传修饰能够应答于环境因素、调控基因表达和信号转导进程。其中，染色质重塑复合物SWI/SNF (SWItch/Sucrose non fermentable, SWI/SNF) 关键亚基Baf60a，在维持机体能量代谢稳态过程中发挥着重要作用。文中重点阐述了生理和病理状态下，Baf60a维持机体脂质代谢、胆固醇代谢、尿素循环及代谢节律性稳态的分子机制。深入探讨以Baf60a为基点的能量代谢调控网络，有望为代谢综合征的改善和治疗提供潜在药物治疗靶点和扎实的研究依据。

Abstract:

Metabolic syndrome is a global chronic epidemic. Its pathogenesis is determined by genetic and environmental factors. Epigenetic modification is reported to regulate gene expression without altering its nucleotide sequences. In recent years, epigenetic modification is sensitively responded to environmental signals, further affecting the gene expression and signaling transduction. Among these regulators, chromatin remodeling SWI/SNF (SWItch/Sucrose non fermentable, SWI/SNF) complex subunit Baf60a plays an important role in maintaining energy homeostasis in mammals. In this paper, we described the pathophysiological roles of Baf60a in maintaining the balance of energy metabolism, including lipid metabolism, cholesterol metabolism, urea metabolism, as well as their rhythmicity. Therefore, in-depth understanding of Baf60a-orchestrated transcriptional network of energy metabolism will provide potential therapeutic targets and reliable theoretical supports for the treatment of metabolic syndrome.