猪肺炎支原体与宿主相互作用研究进展

Interaction between Mycoplasma hyopneumoniae and host—a review

摘要:

猪肺炎支原体 (Mycoplasma hyopneumoniae，Mhp) 是猪支原体肺炎 (Porcine enzootic pneumonia，PEP)的病原体。由于难以建立基因操作平台，也没有成熟的动物模型，这为Mhp致病机制研究增加了极大的困难。但支原体学家仍然在Mhp与宿主互作方面取得了一定进展。文中从Mhp对宿主细胞的黏附、损伤、刺激宿主产生的炎症反应和免疫反应4个方面进行了综述，并对今后Mhp致病机理研究方向进行了展望，以期为后续的Mhp与宿主互作研究提供借鉴，为有效疫苗和药物开发提供理论依据。

Abstract:

Mycoplasma hyopneumoniae is the pathogen of porcine enzootic pneumonia (PEP). Due to difficulties in studying the pathogenesis of M. hyopneumoniae for blockage on the establishment of gene operation platform and immature animal model, mycoplasmologists still make progress in understanding the interaction between M. hyopneumoniae and host. In this paper, we review the adhesion and damage of M. hyopneumoniae to host cells, the inflammatory response and immune response of host stimulated by M. hyopneumoniae. Meanwhile, we propose research directions of the pathogenesis of M. hyopneumoniae in the future. This review can provide references for the follow-up study on the interaction between M. hyopneumoniae and host, and provide theoretical basis for effective vaccine and drug development.