生物体内多胺对蛋白质影响的研究进展

Progress in the effect of polyamines on proteins

摘要:

多胺是普遍存在于生物体中的一种脂肪族阳离子胺。多胺通过离子键和氢键的形式与生物大分子结合，调节生物大分子的生物学活性，调控细胞的生长和发育。多胺对核酸的作用一直是关注热点，而针对蛋白质的影响目前研究较少。本文主要针对多胺调控代谢相关酶、通道蛋白质和其他功能性蛋白质以及相关规律和机制进行综述，并从蛋白质结构和功能角度探讨了多胺与蛋白质之间的相互作用关系，同时总结了多胺与蛋白质相互作用研究在疾病治疗中的应用前景和面临的问题。

Abstract:

Polyamines are a kind of aliphatic amines that exist widely in nearly all organisms. Polyamines interact with biological macromolecules through ionic interactions and hydrogen bonds, thereby they could affect the cell growth via regulating the function of macro-molecules. The impact of polyamines on nucleic acids has been thoroughly studied. However, their effects on protein structure and functions are not well established. This review summarizes the recent progress on how polyamines affect proteins, including metabolic enzymes, ion channel proteins and other important proteins. The interaction between polyamines and proteins is discussed, and the review also summarizes the challenges in studying polyamine-protein interaction as well as the potential application of these studies on the therapy of correlated diseases.