肝癌基因调控网络研究进展

Gene regulatory network of hepatocellular carcinoma: a review

摘要:

肝癌 (Hepatocellular carcinoma，HCC) 是我国常见的恶性肿瘤之一。肝癌基因调控网络 (HCC regulatory network，HCC GRN) 是研究肝癌分子机制的重要途径之一，其节点包括肝癌相关的分子，如miRNA、TF等，网络的边由节点间相互作用关系构成。基于不同类型的数据构建的肝癌基因调控网络其类型及特征各有不同。综合近年来肝癌基因调控网络研究发现，由TF与miRNA构建的肝癌转录调控网络更能揭露肝癌关键基因，反映关键基因在调控网络中的扰动情况。整合基因变异信息与调控网络成为研究肝癌基因调控网络的趋势，但相应的研究几乎是空白的。本文从HCC GRN的数据来源、分类及特征，及各类型调控网络的近年研究情况等方面进行综述，并结合相关研究工作对肝癌基因调控网络研究现状进行分析与讨论，对前景进行展望，为这一领域研究工作提供参考。

Abstract:

Hepatocellular carcinoma (HCC) is one of the common malignant tumors. HCC gene regulatory network (HCC GRN), whose nodes consist of genes, miRNAs or TFs and whose edges consist of interaction relationships of nodes, is one of the important ways to study molecular mechanism of HCC. Based on various experimental data, types of HCC GRNs could be conducted such as TF-miRNA regulatory network. Integrating the studies of HCC GRN, TF-miRNA transcriptional regulatory network performs better in identifying core genes which play important roles in network disturbances. It is a trend that gene variations and transcriptional regulatory networks should be combined, however the corresponding research is almost blank. This review summarizes the source of HCC data sources, the classification, character, and research program of HCC GRN. Finally, according to present analysis and discussion of progress and research status of HCC GRN, we provide a useful reference for researchers.