口蹄疫病毒外源序列插入位点的研究进展

Progress in insertion sites for foreign sequence of foot and mouth disease virus

摘要:

伴随着对口蹄疫病毒 (FMDV) 蛋白结构功能的深入研究，发现FMDV能够表达外源基因片段。通过对FMDV的基因进行改造和修饰研究，进而实现了不同应用目的，如提高病毒滴度、引入标记、提高免疫应答、降低致病性等。文中主要从FMDV接受外源基因插入位点角度来介绍现阶段关于FMDV表达外源基因相关进展。

Abstract:

With the progess in studying gene structure and function of foot and mouth disease virus (FMDV), FMDV can express exogenous genes in different sites. Through transforming and modifying FMDV can achieve different application purposes such as improving virus titer, introducing tag, improving immune responses, and reducing pathogenicity. From the perspective of FMDV receiving inserted exogenous gene, this paper mainly describes the latest relevant developments of FMDV’s expression to exogenous gene.