Cavins: 胞膜窖相关蛋白新视野

Cavins: new sights of caveolae-associated protein

摘要:

胞膜窖 (Caveolae) 是细胞膜内陷形成的一种特殊的脂筏结构，含有丰富的胆固醇和鞘磷脂，并在调节细胞信号转导中发挥重要作用。大量的研究显示，Caveolae标志蛋白窖蛋白 (Caveolins) 在维持caveolae的结构及其功能的调节中发挥重要作用。然而，最近研究发现caveolae的形成同样需要另一类蛋白家族Cavins蛋白家族的参与。此外，Cavins蛋白家族成员之一Cavin-1能够与Caveolins主要成员窖蛋白-1 (Caveolin-1) 相互作用参与调节caveolae的结构和功能。文中将就近年来Cavins与Caveolins的关系及其在调节caveolae中的作用研究进展进行综述。

Abstract:

Caveolae are specialized lipid rafts that form flask-shaped invaginations of the plasma membrane. Many researches show that caveolae are involved in cell signaling and transport. Caveolin-1 is the major coat protein essential for the formation of caveolae. Recently, several reports indicated that the other caveolae-associated proteins, Cavins, are required for caveola formation and organization. It's worth noting that Cavin-1 could cooperate with Caveolin-1 to accommodate the structural integrity and function of caveolae. Here, we reviewed that the relationship between Cavins and Caveolins and explore the role of them in regulating caveolae.