基因工程菌发酵生产L-乳酸研究进展

Recent developments in L-lactate fermentation by genetically modified microorganisms

摘要:

乳酸是重要的工业平台化学品。随着聚乳酸产业的兴起，对高质量L-乳酸的需求量也不断增加。为了进一步降低L-乳酸发酵成本，提高菌株的工业适应性，各种现代生物技术已经应用到L-乳酸发酵菌种的改造上来。文中简要综述了近年来使用乳酸菌、酵母、大肠杆菌及米根霉等基因工程菌株发酵生产L-乳酸的技术进展。

Abstract:

Lactic acid is an important platform chemical. Especially with rapid development of poly (lactic acid) industry, the demand for L-lactic acid is continuously increasing. To further reduce the fermentation costs and improve the robustness of strains from industrial point of view, many modern biotechnological approaches have been applied to strain development. In this review, we briefly summarize recent advances in L-lactate fermentation by genetically modified microorganisms, including lactic acid bacteria, yeast, E. coli and Rhizopus species.