微生物发酵生产5-氨基乙酰丙酸研究进展

Advances in microbial production of 5-aminolevulinic acid

摘要:

5-氨基乙酰丙酸是生物体内吡咯生物合成途径的关键中间产物，具有广泛的应用前景。文中从三方面归纳了国内外关于5-氨基乙酰丙酸的最新研究进展：生产5-氨基乙酰丙酸的微生物筛选分离与诱变；基于C4途径的微生物全细胞生物转化合成5-氨基乙酰丙酸；基于微生物代谢工程改造构建高产5-氨基乙酰丙酸的工程菌株。最后，预测了未来5-氨基乙酰丙酸的研究方向和焦点。

Abstract:

5-aminolevulinic acid is the key intermediate of the tetrapyrrole biosynthesis pathway in organisms and has broad application potentials. This review summarized and discussed recent progress in microbial production of 5-aminolevulinic acid, including screening, isolation and mutation of microbes to produce 5-aminolevulinic acid; microbial whole-cell transformation to synthesize 5-aminolevulinic acid depending on the C4 pathway; construction of high-yield 5-aminolevulinic acid producing strains by metabolic engineering. Finally, future research directions in microbial production of 5-aminolevulinic acid were addressed.