紫杉醇诱导凋亡的信号传导通路及与凋亡相关的基因和蛋白

Paclitaxel induced apoptotic genes and pathways alterations: a review

摘要:

紫杉醇对临床多种恶性肿瘤都有疗效，并具广阔的市场应用前景，其抗癌机制是致使肿瘤细胞发生细胞周期阻滞而凋亡。作者结合课题组多年来的研究，对紫杉醇诱导凋亡过程中的信号通路、相关基因及蛋白进行介绍，包括微生物发酵生产紫杉醇的基因、细胞周期蛋白、端粒酶等。

Abstract:

Taxol has clinical efficacy on many malignant tumors, thus having a good market prospects. The anti-cancer mechanism of taxol is to arrest the cell cycle of tumor cells, leading to apoptosis. Based on our research over the years, we reviewed the latest developments in signaling pathways, the effects of related genes and proteins on apoptosis during paclitaxel-induced apoptosis process, including the paclitaxel-producing gene in microbial fermentation process, cyclin, telomerase of apoptosis.