科微学术
生物工程学报
江苏省科技支撑计划项目 (No. BE2012617)，中组部青年拔尖人才支持计划，江苏省杰出青年基金 (No. BK2012002)，国家高技术研究发展计划 (863计划) (No. 2012AA022 108) 资助。
- Qiulin Wu
Qiulin Wu
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China; Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, Jiangsu, China; Laboratory of Food Microbial-Manufacturing Engineering, Ministry of Education, Jiangnan University, Wuxi 214122, Jiangsu, China
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在本站中查找 - Liming Liu
Liming Liu
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China; Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, Jiangsu, China; Laboratory of Food Microbial-Manufacturing Engineering, Ministry of Education, Jiangnan University, Wuxi 214122, Jiangsu, China
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在本站中查找 - Jian Chen
Jian Chen
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China; Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, Jiangsu, China; Laboratory of Food Microbial-Manufacturing Engineering, Ministry of Education, Jiangnan University, Wuxi 214122, Jiangsu, China
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Key Technologies R & D Program of Jiangsu Province (No. BE2012617), Program for Young Talents in China, Outstanding Youth Foundation of Jiangsu Province (No. BK2012002), National High Technology Research and Development Program of China (863 Program)(No. 2012AA022 108).
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硫酸软骨素是一种典型的硫酸化糖胺聚糖，具有多种药物活性，广泛应用于药品、保健品及化妆品行业。硫酸软骨素是动物软骨中蛋白聚糖的主要成分和少数几种细菌的荚膜多糖，因此可利用动物提取法和发酵法进行生产。以下综述了硫酸软骨素的发酵生产及其合成机制的研究进展，并对其发展趋势进行了展望。
Chondroitin sulfate (CS) is the typical sulfation glycosaminoglycan and widely applied in the industries of pharmaceutical, health products and cosmetic for its peculiar properties. CS is the main component of cartilage proteoglycans in animal and capsular polysaccharide in a few bacteria. CS can be extracted from animal sources and produced via microbial fermentation. In this article, development of chondroitin sulfate by fermentation, biosynthesis and regulating mechanisms of CS in bacteria are described. Furthermore, prospect and tendency of chondroitin sulfate from bacterial fermentation are addressed.
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吴秋林,刘立明,陈坚. 发酵法生产硫酸软骨素的研究进展[J]. 生物工程学报, 2012, 28(11): 1281-1293
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- 收稿日期:2012-04-12
- 在线发布日期: 2012-11-26
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