植物次生代谢途径的遗传操作

Genetic modification of secondary metabolite biosynthesis in higher plants: a review

摘要:

植物次生代谢产物种类极其丰富，是人类的宝贵资源，这些产物及其合成途径相关酶具有空间特异性分布的特征。植物次生代谢途径的调控是个复杂的过程，受代谢产物水平、多酶复合物相互作用等多种因素的影响。通过遗传操作改造代谢过程，调控产物在植物体内的含量，是一条切实可行和具有广阔发展空间的途径。目前，改造植物次生代谢途径可以采取单基因操作和多基因操作两种策略进行。

Abstract:

Plants provide an immense reservoir of natural secondary metabolites. Secondary metabolites and those involved enzymes accumulate in various compartments in specific plant tissues. The biosynthesis of diverse groups of secondary metabolites is often complicated, tightly controlled via network interconnections, metabolite levels, metabolite channeling and multi-enzyme complexes, and so on. Secondary metabolite profiles could be genetically altered by two strategies, i.e. single gene modification and multiple gene modification; which thus has opened a feasible and prospective platform for secondary chemicals production in plant.