肿瘤细胞的自噬和窖蛋白-1

Autophagy and Caveolin-1 in cancer: a review

摘要:

自噬作用是一种细胞通过溶酶体自我降解的过程，在肿瘤的形成和发展中起着双重作用。窖蛋白-1?(Caveolin-1，Cav-1) 作为胞膜窖的标志蛋白，介导许多生理和病理过程，包括胞膜窖的形成、膜泡运输、维持细胞胆固醇稳态、信号转导和肿瘤的发生。近年来，许多研究表明肿瘤细胞自噬和Cav-1存在一定关系。文中就近年来肿瘤细胞的自噬与Cav-1的关系及其在肿瘤发生和发展过程中的作用进行综述。

Abstract:

Autophagy, is an essential cellular process involving self-degradation of intracellular components via the lysosome, which plays the Janus role in cancer initiation and progression. Caveolin-1, a marker protein of caveolae, functions as scaffolding protein mediating many physiological and pathological processes including caveolae biogenensis, vesicular transport, cholesterol homeostasis, signal transduction and tumorigenesis. Recently, many reports showed that autophagy of tumor cells associated with stromal Cav-1. We reviewed that the relationship between autophagy and Cav-1 involved in tumorigenesis and development.