Gp96蛋白的免疫学及其临床应用研究进展

Overview of Gp96 mediated immunity

摘要:

热休克蛋白Gp96属于HSP90家族，是内质网中最丰富的蛋白质之一，在细胞内发挥着分子伴侣的作用。在天然免疫中，Gp96则通过与Toll样受体等相互作用刺激抗原呈递细胞 (如DC等) 产生各种细胞因子激活免疫系统；而在获得性免疫中，Gp96-抗原肽复合物通过抗原交叉将抗原肽呈递给MHC-I类分子，诱发机体抗原特异性细胞毒T细胞免疫应答，清除病原物感染和肿瘤；近年来的研究还发现Gp96具有免疫佐剂的功能。以下从Gp96的生物学特性、免疫学机制以及其在抗病原感染和抗肿瘤免疫中的应用等方面做一小结，为设计以Gp96-抗原肽为新一代疫苗的临床研究提供理论基础。

Abstract:

As a member of the HSP90 family, heat shock protein (HSP) Gp96 is one of the most abundant proteins in the endoplasmic reticulum (ER), which displayed important molecular chaperones function in cells. Gp96 can stimulate the production of cytokines by activating the antigen presentation cells (such as dendritic cell, et al) in innate immunity. It is capable of eliciting an antigen-specific cytotoxic T lymphocyte (CTL) immune response to eliminate pathogens and tumors by facilitating antigen cross-presentation in adaptive immunity. Gp96 is also an ideal adjuvant in many recent researches. Here, we review the progress that addresses the role of biological characteristics, immunogenic mechanism that may be involved in the induction of anti-infection immune response and antitumor immunity, which may guide the new vaccine strategies with the knowledge of Gp96-antigen complexes.