非水酶学和非水相生物催化研究进展

Recent trend of nonaqueous enzymology and biocatalysis in nonaqueous media

摘要:

近年来工业生物技术飞速发展, 酶学和生物催化领域也取得突破性进展, 特别在酶在非水相中活性及稳定性研究, 耐溶剂生物催化剂的筛选、构建、修饰和改造, 生物相容性和环境相容性好的绿色介质等方面取得了较大的进展。最近的研究热点和未来几年的研究方向主要为: 基于基因组信息的耐溶剂酶的虚拟筛选和构建; 基于自然界筛选新酶基因的耐溶剂酶重构和改造; 离子液体等环境友好的绿色介质系统等几个方面。

Abstract:

With the rapid development of industrial biotechnology, breakthrough in enzymology and biocatalysis has been made in recent years, especially in areas of stability and activity of enzyme in nonaqueous media, screening, construction and modification of solvent-tolerant biocatalysts, as well as the development of green solvent with excellent biological and environmental compatibility. Recent trend and future focus include: in silico virtual screening and construction of solvent-tolerant biocatalysts based on bioinformatic technology, modification and construction of native solvent-tolerant biocatalysts, the development of environmental friendly green solvent such as ionic liquids.