核酸、氨基酸分类和蛋白质二级结构关系的分析与分子设计

Relationships of Nucleotide, Amino Acid Sequence and Secondary Structure of Protein and Molecular Design

摘要:

核酸序列中包含一定的蛋白质结构信息。根据通常情况下遗传密码表中密码子中间位的碱基配对时产生的氢键数目，尝试将20种氨基酸划分为两类，并用自编的计算机软件对蛋白质二级结构数据库中两类氨基酸的类聚现象进行了统计分析。结果表明，使用这种方法对氨基酸进行划分后，氨基酸残基具有较大概率与划入同一类的氨基酸残基相邻出现，并且这种聚集体对二级结构具有一定的偏好性。最后按照该方法设计了一段氨基酸序列并给出了预测服务器预测得到的结构。

Abstract:

May the structure information of protein be obtained from the corresponding nucleotide sequence? For this question, a computer program was used to conduct a statistical analysis about the clustering phenomena of amino acids. In this method,20 kinds of amino acid were classified into 2 types according to the number of hydrogen bonds formed by middle base of their correlation codons.It can be seen that amino acid has a rather great possibility of neighboring on another of its class and this assembly has a tendency to forming specific secondary structure. A sequence was designed and its secondary structure was predicted by this prediction software.