人热休克因子1突变体的应用研究进展

Human HSF1 Mutants and Their Applications

摘要:

热休克因子1是调节应激反应的主要转录因子，它在应激条件下可被活化。通过基因突变得到正显性和负显性热休克因子1，它们不需要外界条件刺激就分别具有启动热休克蛋白的表达或竞争抑制内源热休克因子1活性的能力。目前，已有多个热休克因子1的突变体应用于疾病研究。介绍了热休克因子1的结构和活化途径，以及热休克因子1突变体在肿瘤、神经系统及心血管系统等方面的应用进展。

Abstract:

Heat shock factor 1 (HSF1) is the key protein in regulating stress response. It can be activated under heat，oxidative or another stress conditions. Dominant-positive and dominant-negative HSF1 are two types of HSF1 mutants. Both of them gain the DNA binding activity in the absence of stress. In addition，dominant-positive HSF1 acquires transcriptional activity，which dominant-negative HSF1 does not acquire. In this paper，the progress of using these HSF1 mutants in the research of cancer，neurodegenerative disorders and cardiovascular diseases will be discussed.