Abstract:It has been unequivocally proved that the occurrence and development of oral diseases are strongly associated with the imbalance of oral microbiota. Probiotics are live microorganisms that confer health benefits on the host, which exert the probiotic efficacy by the process of secreting antibacterial substances, interfering with the colonization of pathogenic bacteria, modulating the expression of virulence-associated genes, modulating host immune responses, regulating oxidative stress response, involving nitrate-nitrite-nitric oxide pathway, and adjusting the pH value of biofilms. Studies have found that probiotic therapy could reduce the risk of dental caries, promote the periodontal status, and improve the therapeutic effect of oral mucosal diseases, which is expected to be the potential way to prevent and treat oral diseases. This article reviews the researches progress on the relationship between probiotics and oral microecological regulation in recent years.

Abstract:The balance of oral microbiota is a key factor in maintaining oral health. Prebiotics are a kind of organic substances that selectively promote the metabolism of beneficial microorganisms. They mainly exert their functions by adjusting the oral microbial growth and metabolism, inhibiting the formation of dental plaque biofilm, regulating the host immune response and oxidative stress response, and participating in the nitrate-nitrite-nitric oxide pathway. Studies have demonstrated that prebiotics play a positive role in the prevention and treatment of common oral diseases, such as dental caries, periodontal diseases, and oral mucosal disease, and are expected to become a potential way to prevent and treat oral diseases. This article reviews the recent research progress in prebiotics, their effects on oral health, and the mechanisms of prebiotics in regulating oral microecology.