Research status and application progress of Bacillus subtilis in the fields of medicine and functional foods

Abstract:

Bacillus subtilis serves as a widely used elite microbial platform, playing a pivotal role in biomedicine and food industries. It is extensively employed in synthesizing a variety of enzymes, compounds, pharmaceuticals, and health products. The advancing genetic engineering and metabolic engineering approaches, together with comprehensive genomic sequences, genetic toolkits, and bioinformatics tools enable exploring the potential applications of B. subtilis. This exploration offers valuable guidance for related industries. Nonetheless, challenges remain in optimizing metabolic pathways to enhance desired yields, investigating the synthesis potential for other substances, and developing more efficient adapter biobricks. Additionally, ensuring the safety of B. subtilis in biomedicine and food is crucial to prevent adverse effects. This review encapsulates the use of B. subtilis in biosynthesis of medicine and functional foods, discusses the current application status of B. subtilis as a future green and safe microbial platform, and prospects the trends and technical development of its products. This review lays the groundwork for further probing into the application and economic value of B. subtilis, showcasing its immense potential for green and sustainable development.