Research progress in the synthesis of terpenoids from Yarrowia lipolytica

Abstract:

Yarrowia lipolytica is a species of unconventional lipid-producing yeast with a well-defined genetic background and a comprehensive suite of gene editing tools. Terpenoids are natural secondary metabolites with isoprene as the basic structural unit and are ubiquitous in nature. In recent years, with the rapid development of synthetic biology, the synthesis of terpenoids by metabolic engineering has attracted increasing attention. In this paper, we reviewed the metabolic engineering in Y. lipolytica for the synthesis of terpenoids from enhanced precursor supply, subcellular organelle synthesis, and carbon source utilization. In addition, this paper envisions the potential research directions, with a view to providing guidance for the following research.