Progress in the regulation of morphological differentiation and secondary metabolism of Streptomyces by the transcriptional regulator BldD

Abstract:

Streptomyces is a genus of Gram-positive soil bacteria with complex morphological differentiation and life cycle. It has strong secondary metabolic capacity and can produces a variety of antibiotics. The growth of Streptomyces is often associated with morphological differentiation and secondary metabolism, which involve complex regulatory mechanisms, including pathway-specific regulation, pleiotropic regulation, and global regulation. The bld gene family is essential for the normal morphological development of Streptomyces and named since its deletion causes the “blad” phenotype. BldD, a global regulator encoded by a member of the bld family, can significantly regulate the morphological differentiation and secondary metabolism of Streptomyces. This review introduces the structure of BldD and the effects of BldD on the morphological differentiation and secondary metabolism of representative strains of Streptomyces, providing a reference for revealing the molecular regulatory mechanism of BldD in Streptomyces.