Research progress in the pathogenesis and treatment of human brucellosis

Abstract:

Human brucellosis is a zoonotic disease caused by the facultative intracellular pathogen Brucella. Humans often become infected through direct contact with infected animals or by eating animal products. Because of the unspecific clinical manifestations, brucellosis is easy to become chronic without timely diagnosis and treatment, which seriously affects the quality of life of the patients. Therefore, understanding the pathogenic characteristics of the pathogen, the mechanism of host-pathogen interaction, and the current treatment status can provide a new direction for the clinical diagnosis and treatment of brucellosis. This paper describes the infection mechanism of Brucella, the innate and adaptive response mechanisms of the host (human), and the current clinical characteristics and treatment strategies of brucellosis, aiming to provide reference for the prevention and treatment of human brucellosis.