Gut microbiota-targeted therapeutic strategies for autism spectrum disorders

Abstract:

The role of gut microbiota in autism spectrum disorders (ASD) is receiving increasing attention and may become an important direction for ASD treatment in the future. Studies have shown that the gut microbiota in ASD patients is different from that in healthy people in terms of microbial relative abundance, diversity and so forth. These microorganisms can influence the development and function of the nervous system via multiple pathways along the microbiota-gut-brain axis, which affects the behaviors and cognitive abilities of ASD patients. Therefore, modulating the gut microbiota may be an effective therapy for ASD. Researchers have explored the efficacy of probiotics, fecal microbiota transplantation, and other therapies for ASD and have made preliminary progress. However, studies remain to be carried out to determine the optimal therapeutic strategies with long-term efficacy and high safety.