Home > Archive>Volume 51, Issue 6, 2024 >1834-1853. DOI:10.13344/j.microbiol.china.240047
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Research progress in the demethylation mechanism of lignin biodegradation
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    Abstract:

    Lignin is a heterogeneous aromatic biopolymer composed of diverse aromatic monomers linked by various types of chemical bonds, which make the efficient degradation and cost-effective transformation of lignin a formidable global issue. Recent studies have discover unique non-specific redox systems inherent in microorganisms and the metabolic capacity of microorganisms for degrading aromatic compounds, shedding light on lignin valorization. Given that most of lignin-derived aromatic monomers contain methoxy groups, demethylation emerges as a rate-limiting step in the metabolism of these compounds. This review offers an extensive summary of the latest studies about the biological and enzymatic mechanisms of demethylation during the biodegradation of lignin. Meanwhile, by examining exemplary studies on lignin valorization with novel aromatic demethylases, this paper highlights the pivotal role of understanding microbial demethylation mechanisms and mining new demethylases in lignin degradation and transformation.

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    [63] 湚搀?椀琀猀?瀀栀愀爀洀愀挀漀氀漀最椀挀愀氀?瀀漀琀攀渀琀椀愀氀嬀?崀???匀刀一?倀栀愀爀洀愀挀漀氀漀最礀???　?????　????????????戀爀?嬀??崀?伀吀匀唀???夀??一????唀刀?????匀??????刀?????匀唀???唀刀???????匀??????伀??刀??匀????吀?夀????夀???昀昀椀挀椀攀渀琀?瀀爀漀搀甀挀琀椀漀渀?漀昀???瀀礀爀漀渀攀??????搀椀挀愀爀戀漀砀礀氀椀挀?愀挀椀搀?愀猀?愀?渀漀瘀攀氀?瀀漀氀礀洀攀爀?戀愀猀攀搀?洀愀琀攀爀椀愀氀?昀爀漀洀?瀀爀漀琀漀挀愀琀攀挀栀甀愀琀攀?戀礀?洀椀挀爀漀戀椀愀氀?昀甀渀挀琀椀漀渀嬀?崀???瀀瀀氀椀攀搀??椀挀爀漀戀椀漀氀漀最礀?愀渀搀??椀漀琀攀挀栀渀漀氀漀最礀???　　???????????　???????戀爀?嬀??崀?刀伀匀?一????????刀刀??伀?倀??倀伀?????伀一??????攀洀攀琀栀礀氀愀琀椀漀渀?漀昀?瘀愀渀椀氀氀椀挀?愀挀椀搀?戀礀?爀攀挀漀洀戀椀渀愀渀琀??椀最??椀渀?愀?漀渀攀?瀀漀琀?挀漀昀愀挀琀漀爀?爀攀最攀渀攀爀愀琀椀漀渀?猀礀猀琀攀洀嬀?崀???愀琀愀氀礀猀椀猀?匀挀椀攀渀挀攀??愀洀瀀??吀攀挀栀渀漀氀漀最礀???　??????????????????????戀爀?嬀??崀?倀夀一??????一?刀?刀伀匀匀?????????刀??????嘀嘀???????伀伀??刀????匀?????吀????????刀吀?一?嘀?????渀?攀渀最椀渀攀攀爀攀搀??爀漀??瀀爀漀琀攀椀渀?搀攀最爀愀搀愀琀椀漀渀?愀瀀瀀爀漀愀挀栀?昀漀爀?椀渀挀爀攀愀猀攀搀??椀?挀椀猀??椀???椀?挀椀猀??椀??洀甀挀漀渀椀挀?愀挀椀搀?戀椀漀猀礀渀琀栀攀猀椀猀?椀渀??椀?匀愀挀挀栀愀爀漀洀礀挀攀猀?挀攀爀攀瘀椀猀椀愀攀??椀?嬀?崀???瀀瀀氀椀攀搀?愀渀搀??渀瘀椀爀漀渀洀攀渀琀愀氀??椀挀爀漀戀椀漀氀漀最礀???　????????????攀　?　???攀　?　????戀爀?嬀??崀?圀唀?圀????唀吀吀??吀??嘀?刀??一??????唀??匀??????一???一匀?一?????伀儀唀??愀挀甀琀攀?????匀?一???匀???椀最渀椀渀?瘀愀氀漀爀椀稀愀琀椀漀渀??琀眀漀?栀礀戀爀椀搀?戀椀漀挀栀攀洀椀挀愀氀?爀漀甀琀攀猀?昀漀爀?琀栀攀?挀漀渀瘀攀爀猀椀漀渀?漀昀?瀀漀氀礀洀攀爀椀挀?氀椀最渀椀渀?椀渀琀漀?瘀愀氀甀攀?愀搀搀攀搀?挀栀攀洀椀挀愀氀猀嬀?崀??匀挀椀攀渀琀椀昀椀挀?刀攀瀀漀爀琀猀???　??????????　??戀爀?嬀??崀?一獧???????栀腧????晾聛??????皉??顣?葎鑶??喏孜?崀??????畓????　???????????????????????夀?????一??匀??夀?一???堀???瀀瀀氀椀挀愀琀椀漀渀?瀀爀漀最爀攀猀猀?漀昀?漀洀椀挀猀?琀攀挀栀渀漀氀漀最礀?漀渀?氀椀最渀椀渀?搀攀最爀愀搀椀渀最?攀渀稀礀洀攀?猀礀猀琀攀洀?洀椀渀椀渀最嬀?崀???漀漀搀?愀渀搀??攀爀洀攀渀琀愀琀椀漀渀??渀搀甀猀琀爀椀攀猀???　?????????????????????椀渀??栀椀渀攀猀攀???戀爀?嬀??崀?吀????伀刀??匀???伀??一????匀??吀栀攀?爀漀氀攀?漀昀?挀礀琀漀挀栀爀漀洀攀猀?倀???　?椀渀?愀搀爀攀渀愀氀?猀琀攀爀漀椀搀漀最攀渀攀猀椀猀嬀?崀??吀爀攀渀搀猀?椀渀??椀漀挀栀攀洀椀挀愀氀?匀挀椀攀渀挀攀猀???????????????????????戀爀?嬀??崀?謀啛???殚???镔???辍獹??杹?????犀?偽??　瘀蒑?葾?鼰??鑎??癸?喏孜?崀????極晲?????　?　???????????????????匀伀一??娀????伀?堀??圀唀?????唀??倀??儀?一?????匀琀爀甀挀琀甀爀攀??昀甀渀挀琀椀漀渀??愀渀搀?愀瀀瀀氀椀挀愀琀椀漀渀?漀昀?挀礀琀漀挀栀爀漀洀攀?倀??　?攀渀稀礀洀攀猀嬀?崀???椀挀爀漀戀椀漀氀漀最礀??栀椀渀愀???　?　????????????????????椀渀??栀椀渀攀猀攀???戀爀?嬀?　崀??唀?一??刀?????倀???礀琀漀挀栀爀漀洀攀?倀??　?爀攀猀攀愀爀挀栀?愀渀搀??椀?吀栀攀??漀甀爀渀愀氀?漀昀??椀漀氀漀最椀挀愀氀??栀攀洀椀猀琀爀礀??椀?嬀?崀??吀栀攀??漀甀爀渀愀氀?漀昀??椀漀氀漀最椀挀愀氀??栀攀洀椀猀琀爀礀???　????????????????????　??戀爀?嬀??崀??唀?倀?刀?????嘀?一匀?刀??倀刀?吀娀???????刀??一?吀?????唀刀一伀嘀????刀伀一一???刀??刀?伀??吀唀一夀?匀唀嘀唀一??伀伀???????吀?匀?刀??????????愀挀甀琀攀????????倀伀吀?倀?一?伀?????刀?????一???????夀?刀?????伀???匀?????????刀???????伀圀??????刀伀??刀??倀?刀???匀????一??伀?伀嘀?匀?????一?刀??????刀?????????吀??攀琀?愀氀???椀最栀氀礀?愀挀挀甀爀愀琀攀?瀀爀漀琀攀椀渀?猀琀爀甀挀琀甀爀攀?瀀爀攀搀椀挀琀椀漀渀?眀椀琀栀??氀瀀栀愀?漀氀搀嬀?崀??一愀琀甀爀攀???　??????????????????戀爀?嬀??崀?夀?一??????娀??伀????圀唀?夀圀???栀攀洀椀挀愀氀?猀礀渀琀栀攀猀椀猀?愀渀搀?戀椀漀氀漀最椀挀愀氀?昀甀渀挀琀椀漀渀?漀昀?氀椀瀀椀搀愀琀攀搀?瀀爀漀琀攀椀渀猀嬀?崀??吀漀瀀椀挀猀?椀渀??甀爀爀攀渀琀??栀攀洀椀猀琀爀礀???　??????????????????戀爀?嬀??崀???????刀????刀????一?嘀刀??愀挀甀琀攀?吀??伀嘀??愀挀甀琀攀??嘀??倀??伀一??夀愀挀甀琀攀?伀嘀??愀挀甀琀攀???????娀???刀?嘀????刀???????一娀?一?????刀?倀??伀吀夀?倀???????攀洀戀爀愀渀攀?愀琀琀愀挀栀攀搀?洀愀洀洀愀氀椀愀渀?挀礀琀漀挀栀爀漀洀攀猀?倀??　??愀渀?漀瘀攀爀瘀椀攀眀?漀昀?琀栀攀?洀攀洀戀爀愀渀攀?猠?攀昀昀攀挀琀猀?漀渀?猀琀爀甀挀琀甀爀攀??搀爀甀最?戀椀渀搀椀渀最??愀渀搀?椀渀琀攀爀愀挀琀椀漀渀猀?眀椀琀栀?爀攀搀漀砀?瀀愀爀琀渀攀爀猀嬀?崀???漀甀爀渀愀氀?漀昀??渀漀爀最愀渀椀挀??椀漀挀栀攀洀椀猀琀爀礀???　?????????????????, JOHNSON CW, BECKHAM GT. Metabolism of syringyl lignin-derived compounds in Pseudomonas putida enables convergent production of 2-pyrone-4,6-dicarboxylic acid[J]. Metabolic Engineering, 2021, 65: 111-122.
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WU Yanling, XUE Le, LU Peng, LI Andong, LIAO Qingzhao, CHEN Xianrui, XIAO Ning, XIE Shangxian. Research progress in the demethylation mechanism of lignin biodegradation[J]. Microbiology China, 2024, 51(6): 1834-1853

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  • Received:January 15,2024
  • Adopted:March 19,2024
  • Online: June 07,2024
  • Published: June 20,2024
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