Research progress in immunogenicity of outer membrane proteins of Brucella

Abstract:

Brucellosis, caused by the bacteria of Brucella, is considered one of the major zoonotic diseases worldwide. As the key virulence factors of Brucella, outer membrane proteins not only play a vital role in the host immune process against Brucella but also are potential immunogens and protective antigens of Brucella. These proteins can stimulate strong immune response of the host and be used as diagnostic antigens and targets of novel vaccines against Brucella. We reviewed the research progress in the immunogenicity of key outer membrane proteins of Brucella, aiming to provide a reference for laboratory diagnosis and new vaccine development against Brucella.