Biosynthesis and molecular regulation of lincomycin: a review

Abstract:

Lincomycin, an amide antibiotic produced by Streptomyces lincolnensis, is mainly used to treat infections caused by Gram-positive bacteria in clinical practice. In view of its high medicinal value and economic value, progress has been achieved in the biosynthesis and molecular regulation of lincomycin. This review introduces the structural features and biosynthesis of lincomycin, and summarizes the research progress in the molecular regulatory mechanism of lincomycin in S. lincolnensis. The review is conducive to the in-depth understanding of the secondary metabolic regulatory network of S. lincolnensis and provides theoretical guidance for the transformation of regulatory factors or their target elements in the strains with high yields of lincomycin.