Home > Archive>Volume 50, Issue 9, 2023 >4206-4219. DOI:10.13344/j.microbiol.china.230262
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Research progress in the relationship between gut microbiota-derived extracellular vesicles and liver diseases
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    Abstract:

    Extracellular vesicles (EVs) are a type of lipid bilayer membrane vesicles, which can be secreted by a variety of cells. EVs as the key players of interkingdom crosstalk participate in the transmission of signals between prokaryotes and eukaryotes to regulate biological processes. In gut ecosystems, microbe-host communication usually does not involve direct cell contact. Microbiome-derived and host-derived EVs are key participants in such interkingdom crosstalk. The gut-liver axis plays a bridging role in the interaction between gut microbiota and the liver, that can modulate liver diseases including alcoholic fatty liver disease. Recent studies have demonstrated that gut microbiota-derived EVs play a key role in liver diseases. This article summarizes the research progress in gut microbiota-derived EVs, especially the mechanism of EVs production, the contents of EVs, bacteria-host interaction and its role in liver diseases.

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JIA Wenxin, WANG Lirui. Research progress in the relationship between gut microbiota-derived extracellular vesicles and liver diseases[J]. Microbiology China, 2023, 50(9): 4206-4219

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  • Received:March 31,2023
  • Adopted:May 22,2023
  • Online: September 04,2023
  • Published: September 20,2023
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