Progress in the pathogenesis and treatment of irritable bowel syndrome based on the brain-gut-microbiota axis

Abstract:

Irritable bowel syndrome (IBS) is one of the common functional bowel diseases, which lacks clinical features that can be explained by organic diseases. Recent studies describe the pathogenesis of IBS as the disturbance of the brain-gut-microbiota axis, emphasizing the mediating role of gut microbiota in regulating brain-gut interactions. Traditional Chinese medicine (TCM) has been applied to the regulation of brain-gut homeostasis for a long time and demonstrated good efficacy. However, the correlation between TCM and brain-gut homeostasis remains to be studied. We reviewed the TCM and western medicine studies of IBS involving brain-gut-microbiota axis based on the interaction between brain-gut axis and TCM and our previous work, aiming to provide a reference for researchers in this field.