Intestinal microbiome in the prevention and treatment of diabetic kidney disease

Abstract:

Diabetic kidney disease (DKD) is a serious metabolic disease caused by diabetes mellitus. In high glucose, DKD causes chronic inflammation and oxidative stress in the kidney, destroys the physiological structure of the kidney, and leads to renal interstitial fibrosis. Numerous studies have shown that intestinal microbiome influences the body’s metabolism and health. This review summarized the latest research findings on the relevance of the intestinal microbiota to DKD, which aimed to elucidate the effects of the intestinal microbiota on the prevention and treatment of DKD. In addition, the association between intestinal barrier and intestinal microbiome metabolism with DKD was established, and the related mechanisms of the intestinal microbiome against DKD in recent studies were summarized. What’s more, the feasibility of supplementing prebiotics and probiotics as well as fecal transplantation in the treatment of DKD was discussed. By combing relevant content, this review provides certain theoretical references and data support for the treatment of DKD.

Key words:intestinal microbiome;diabetic kidney disease;mechanism;prevention and treatment