Gut microbiota-derived metabolites in irritable bowel syndrome

Abstract:

Irritable bowel syndrome (IBS) is the most common functional bowel disorder with the typical clinical symptoms such as abdominal pain, abdominal distension, and changes in bowel habits. Although the pathogenesis of IBS is complex and has not been fully understood, it has been proven to be related to the abnormal regulation of microbiota-gut-brain axis. The effects of derivative metabolites mediated by the microbiota, such as neurotransmitter, short-chain fatty acids, and bile acids metabolites, on the development of IBS symptoms (visceral sensitivity, abdominal pain, diarrhea and mental disorders) were systematically summarized. This study is expected to provide a new insight for the treatment of IBS with metabolites transforming bacteria as targets.

Key words:irritable bowel syndrome;microbiota-gut-brain axis;5-hydroxytryptamine;short-chain fatty acid;bile acids metabolites