Identification of key factors affecting liquid fermentation of Ganoderma lucidum for triterpenes: a review

Abstract:

Triterpenes, a major group of key components in the medicinal and edible Ganoderma lucidum in China, have crucial pharmacological activities. Liquid fermentation is the most promising way to produce the triterpenes as this method enables short growth cycle, has controllable environmental conditions, yields target products of stable quality, and is suitable for large-scale production. The metabolic pathway of triterpenes, fermentation process parameters, and dissolved oxygen are the key to the liquid fermentation of G. lucidum for triterpenes. In this study, we summarized the effect of metabolic pathways for triterpene biosynthesis and the related enzymes (genes), liquid fermentation process, and dissolved oxygen control regulated fermentation parameters on the biosynthesis of triterpenes, as well as the future research directions, hoping to serve as a reference for the regulation and high-yield production of triterpenes by submerged liquid fermentation.