Research progress on gut microbiota and cognitive impairment in the elderly

doi:10.13344/j.microbiol.china.220469

Home > Archive>Volume 50, Issue 2, 2023 >697-708. DOI:10.13344/j.microbiol.china.220469

Research progress on gut microbiota and cognitive impairment in the elderly
DOI:
                        10.13344/j.microbiol.china.220469
                    
CSTR:
                        32113.14.j.MC.220469
                    
Author:
                        WEN NanaWEN Nana
Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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ZHENG GuohuaZHENG Guohua
Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;School of Nursing and Health Management, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China
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Abstract:

Cognitive decline, a major characteristic of brain aging in the elderly, is associated with the increasing inflammatory reaction, decreasing antioxidant capacity, the impairment of blood-brain barrier, and the structural change of hippocampus. Increasing studies have demonstrated that the changes of gut microbiota in the aging people are an important factor of cognitive impairment, which have gradually become a research hotspot. Gut microbiota can regulate the cognitive function of the elderly through gut-brain axis. They can affect the memory, emotion, and other cognitive domains of the elderly through the neurotransmitters, vagus nerve, nerve endocrine, and immunomodulation. Moreover, they can influence the cognitive function by regulating the beta-amyloid deposition, lipopolysaccharide levels, and the development and maturation of microglia. We reviewed the recent advances in research on gut microbiota and cognitive functions of the elderly, aiming to provide new ideas for the prevention and rehabilitation of cognitive impairment-related diseases in the elderly.

Key words:gut microbiota;brain-gut axis;cognitive impairment;β-amyloid;lipopolysaccharide;microglia

Reference

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[38] PARKER A, FONSECA S, CARDING SR. Gut microbes and metabolites as modulators of blood-bra?扮爠?孡??嵩????婮??婧?啩?????啤传?奲塡???啨?塡偬??兛?九?????甠瑍?浣楲捯牢潥扳椬漠琲愰′爰攬朠由氱愨琲攩?挱漳朵渭椱琵椷瘮攼?摲放晛椳挹楝琠獋?愦湕摵?慬活祂汅潒椠摐?搠敍灅潕獒楅瑒椠潓湋?椠湌?慍?浅潒摔敚氠?漬映??汈穗桁敒楚洠敒爬?獚?摃楈獅敌愭獇敒孁?崠???潂畒牁湕慎汓?潈晗?义敇甠牔漬挠案敕浒楋獁琠牓礬???き休ぎ??????????????????戮爠?孥??嵥???呮?卯呦???剰????佩??匲???????乢????剳?佢??????????????????????摳敢?佯??噳??剮????偲???楴灥潮灴漠汣祯獬慯据捩桺慡牴楩摯敮?楷湩摴畨挠敳摥?湭敥畮牴潥楤渠晦汩慬浡浭慥瑮楴潯湵?愠獢?慣?扥牲楩摡杛敊?琮漠?畮湴摥敲牮獡瑴慩湯摮?湬攠畊牯潵摲敮条敬渠敯牦愠瑍楯潬湥季?嵬???湓瑣敩牥湮慣瑥楳漬渠愲氰′?漬甠爲渲愨氲″漩昺??漱氵收挮甼汢慲爾?匴挰楝攠湋捉敍猠??水????????????㈠????扉牍?字??嵐???丠??倠???丠?夬删?义?????????嘠??????乏?唠??????啎删????乌?剅???听唠佃?奏????????卅传乄??删?????婗?丠乍??之???华敇氠敉挮琠楔癲敡?楳湦捥牲攠慯獦攠獡?潨晥?扬楴晨楹搠潭扩慣捲瑯敢物楯慴?椠湲?杤畵瑣?浳椠捡牭潹晬汯潩牤愠?楮浤瀠牴潡癵攠?桡楴杨桯?景慧瑹?摩楮攠瑡?椠湁摬畺捨敥摩?摥楲愧扳攠瑤敩獳?楡湳?洠楡据敩?瑡桬爠潭畯杤桥?慛?浝攮挠桇慵湴椬猠洲‰愲猰猬漠挶椹愨琲攩携′眸椳琭栲?攴渮搼潢瑲漾硛愴攱浝椠慚孈?嵏???椬愠扂敉琠潗氬漠杘楉慁?????????じ?ㄠ????????水?????扇爠?字??嵌?娠??丬??奅??婗??乗??升??????????唬传?奕????传乚??夠呌????乥?塲塯??婦??乭???坩??娠?佮啤?奣??娠?啹传?塩婰??坯?乹??婣塣??婲??佥?塣?????丠?塯?????佶?夠???奡啩???????乮???卣??婊??传?卣兩??却啩书?????坰?乲???夠?‰報唹?圠??儵唷?????敲琾?愴氲???甔瓋?洠楾挘爬漠拄槯漬琠慘′搜礮猠戏槶漨珆槞玟?瀨犤濥涟濽璜斍猭?愔杶旛?牛敊汝愮琠攭擽?愻瑯犰槣懜氋?暲椬戠爲椰氲氱愬琠椱漹渨′戩示?氹椹瀭漲瀰漲氮礠獆慅捉挠桅慌爬椠摇敕?慙測搠?杕汁畎捇漠獋攬?楐湁摎甠捌敘搮?慁捤瑶楡癮慣瑥楳漠湩?漠晭?乣?副偧??楡渠晦汵慮浣浴慩獯潮洠敩孮?嵣???慩牴摩楶潥瘠慤獹捳畦汵慮牣?剩敯獮敛慊牝挮栠???の????????????????????扄物?孴??嵣??佅???????乮??????剩奮啡?夠??′倱?删???夲??????????乩佮???剩???坥?丮???夾???????????????卌???????????甠浔慒湁?杌畉瑎?流椬挠牏漧打楕潌瑌慉??楎??本愠瑃桒潉打慐捉畅氠畆洬?才畏瑌祏牎楅捙椠灒牄漬搠畃捏敔湔獅??楐??椠浄灉牎潁癎攠獔?挬漠权湒楙瑁楎瘠敊?椮洠灇慵楴爠浭敩湣瑲?楢湩??偡匠?楥湰摬略捴敩摯?愠湦摲??倠健?偲卬??浡潤畯獬敥?浣潥摮散汥猠?潮映??汣穥栺敩業浰敬物?獡?摩楯獮敳愠獦敯孲?嵢??乩畮琠牡楮瑤椠潢湥?剡敶獩敯慵牲捛桊??㈠あ???????????ど???戠牡?孤??嵭?奵佮卩????′丰?‵??伴吸伺?吶??失???匼??吾??吴??坋?呍?乙?????????夬?卋???呈??呓???呭??呵???佲匠???乲????吠?乡佣?乯??侱娠?坮?????卥?卬????乮????婥佶?啬????吠?????乩??婲????剩佳呥??奥??佮??坭??坤??奯??????呥????剡?呲???????椮??慳捹瑣敨牯潧楥摲敩獡?癲畩汣杳愺瑴畨獥??楦??慣湩摡??楊??慲据瑡敬爠潯楦搠整獨?搠潊牡数楡??楳??牐敳摹畣捨敯?来畲瑩?浴楲捩牣漠打楯慣汩?汴楹瀬漠瀲漰氱礷猬愠挱挷栨愴爩椺搲攲?瀭爲漳搰甮挼瑢楲漾湛?愵湝搠?楁湏桕楒扉椠瑅?愠瑔桚敁牒潁猠捏氬攠牚潅獎楅獌孁?崠???楇牅捏畒汇慏瑐楏潕湌??㈠こ?????????㈠?????????????扵牭?孲??嵥?乲?女??????剴佯呲??吠????据??噴?剳丠??????楤挭犲漠杰汲楯慤?摣整癩敯汮漠灡浮敤渠瑤?慣湲摥?晳略湳挠瑡業潹湬孯?嵤???湡湱畵慥氠?副敲癭楡整睩?潮映??浤洠畧湬潩污潬朠祲???は????????????じ???戠牭?孤??崠?????????六?割??匠???????呛婊???????????卯卦???????婭??丧??乄?即????椺捊牁潄戬椠漲洰攱?洬椠挶爰漨朱氩椺愱?挵漭渱游攱挮琼楢潲渾獛?瘶楝愠?璎根攬?林痧璗?戠爱憁椬渠?態砇椬猠宋?崮??咲栱攭??潜用犄渏懶氨?濞曹??磹灻斄牞槏浲旆滞琟慘沄??敛摁楝振椯渲攰?″?みㄜ????ㄧ????????????戠爲?嬱??崲?圶?丠??奉倠????乌?奎??坚?丠??????娠??乎??剋???啗佁?塇吠??娠?书??奣奴??坯啦?坁??娭??中??塤???坤?乭?????呬剩??㈠?慥浬敬汳椠潯牮愠瑳敵獲?湩敶畡牬漠楯湦映汮慥浵浲慡瑬漠牳祴?牭攠獣灥潬湬獳攠?慩渾摩?挠潶杩湴楲瑯椼瘯敩￣楛流灝愯椯牓浥敬湥瑣?癥楤愠?偡??????呦??潵硡佮?慤?獮楧朠湐慨污楲湭条?灩慳瑴桳眧愠祗?楥湫??氠穃桯敮楦浥敲牥?獣?搠楩獮攠愲猰攱″浛楃捝攮嬠?嵵???杺楨湯杵??有?㈱??′?财??の???ど????㈩??????戴爷?嬠??嵅????传?婄???十啇乁??堠??????乏卋?呖?剃??呖匮????偯?並?????※婢??佩?????坲?乥??塢??呡?乤???圠??圠?乬??婥乩??????即????????吠??汨楥捲攠湮獥敵獲?潤湥汧祥?桥敲慡汴瑩桶祥?捤敩汳汯獲?瑥潲?灛牊潝氮椠晎敡牴慵瑲敥?摒略牶楩湥杷?椠湎橥畵牲祯?楯湧摹甬挠攲搰??椬??攴琨愳瀩氺愱猳椳愭??椰?嬼?嵲???愸獝琠牄潅敁湎瑅攠牒漬氠潗杕礠??水????????????休?ぉ?㈠???教?ぎ??扄爬?孈??嵍??刬丠奘??????乁???剉?????????搠敂??么????匬???????呒?丠????坕????传??剎?倠??匬吠?卅婎?坉华???佊????噮????????剄?乗?匬??啌???????????佌?噐?呡?????佤?卢????买?????啥???呴??卡??坩??删婭????噴??唠呤?剦??佲略浮汴????乢?佡????啦书??????删剁?呥呴?圠卩???捯?佭女??????????乮????‰???匴吳??????″倭??匴吮????剛???????吠????偋剉?丠婊?????潍猠瑍?洮椠捒牥潤扵楣潴瑩慯?挠潯湦猠瑬慯湮瑧氭祴?捲潭渠瑰牯潴汥?浴慩瑡畴物慯瑮椠潡湴?慓湣摨?晦畦湥捲琠楣潯湬?潡晴?浲楡捬爭潃杁氱椠慳?楮湡?瑳桥敳??乮匠孴?嵥??乡慴琠畨物数?乯散畡牭潰獵捳椠敡湴挠整??㈠ち????ㄠ??????????????扢牵?孡??嵣???卥呮???佩?剮啛?婝?????传卋??奥??????佲剮????????啹即卩?????????啨???剡呣佯乬?????剦啦卩婣?佡坬匠??????????传?卨???????坮?剐周婹??呯?????卡卬??乯??????佡剮??剴?乥???呲桥敡?洠楓捯牣潩扥楴潹琠慯?椠湐晨污畲敭湡捣敯獬?捧敹氬氠′搰攱愷琬栠′愱渨搴?洺椴挲爳漭朴氲椸愮氼?捲漾汛漵渰楝稠慗瑁楎漠湍?椬渠?瑅栠教?瀠敌牉楎渠慈瑙愬氠?浕漠留猬攠?扉牁慎楇渠孓?崬???牁愠楒測???攠桊慑瘬椠潑牉??慐湔搬??浕流畎湇椠瑃祗???ぁ????????????水??HENG GH. Deviations in hippocampal subregion in older adults with cognitive frailty[J]. Frontiers in Aging Neuroscience, 2021, 12:615852.

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WEN Nana, ZHENG Guohua. Research progress on gut microbiota and cognitive impairment in the elderly[J]. Microbiology China, 2023, 50(2): 697-708

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Received:May 07,2022
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Online: February 03,2023
Published: February 20,2023

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