Autophagy induced by porcine deltacoronavirus infection: a review

Abstract:

Autophagy is a cellular process that removes unnecessary or dysfunctional components through a lysosome-dependent regulated mechanism. It occurs in the presence of stimuli such as virus to maintain homeostasis. Autophagy can help defend against viral invasion and may promote viral replication. Porcine deltacoronavirus (PDCoV) can induce autophagy. In this paper, we summarize the types and process of autophagy, interaction of autophagy with PDCoV, and related detection methods, to elucidate how autophagy resists the infection and supports the replication of PDCoV. The findings are expected to serve as a reference for further research on the pathogenic mechanism of PDCoV and prevention and control of this virus.