Role of cGAS-STING signaling pathway in livestock and poultry diseases: a review

Abstract:

The cGAS-STING signaling pathway is an intracellular DNA sensor that recognizes self-lesioned or externally entered double-stranded DNA in the cytoplasm. It not only is associated with tumors, viral and bacterial infections, and autoimmune diseases but also plays a role in the nonspecific immune system. The available studies of cGAS-STING signaling pathway mainly focus on mammalian tumor-related diseases and the diseases related to the innate immune system. Considering the significant regulatory role of CGAS-STING signaling pathway, we comprehensively expound the role of this pathway in pathogen infection of livestock and poultry, with an view to provide a theoretical basis for the prevention and control of livestock and poultry diseases.