Application of foreign body infection models in the biofilm of Staphylococcus spp.: a review

Abstract:

Persistent infection and drug resistance caused by the biofilm of Staphylococcus spp. have always been a difficult problem in clinical treatment. The research on the molecular mechanism of biofilm formation has become the key to the prevention and treatment of infections associated with the biofilm of Staphylococcus spp.. The establishment of animal models of infection by Staphylococcus spp. is conducive to the study of biofilm formation, diffusion, and pathogenesis and the in vivo evaluation of the anti-biofilm effect of drugs. However, there are many influencing factors of biofilm formation in animals, such as animal species, implantation material, inoculation site, infection dose, observation time, and evaluation method. This study systematically summarized the animal models of biofilm infection by Staphylococcus spp. in the past 40 years, focusing on the establishment methods, application scope, advantages, and disadvantages of animal models, thereby providing a theoretical basis for the prevention and treatment of biofilm infection by Staphylococcus spp..