Skin-gut axis and atopic dermatitis from the microbial perspective

Abstract:

Atopic dermatitis (AD) is an intractable and relapsing skin disease that has become a concern in the public health field due to its complex etiology and increasing prevalence year by year. With the application of high-throughput sequencing, metagenomics, metabolomics, and other technologies, it has been found that the occurrence and development of AD are closely related to the microbial community, and the “microbiota-skin-gut” axis and the crosstalk mechanisms between them have also been gradually verified. The “microbiota-skin-gut” axis has played an important role in allergic skin inflammation. This article reviews the relationship between the “microbiota-skin-gut” axis and AD, and the signaling molecules and potential pathways it may communicate with. Significant attention has been paid to the potential mechanisms involved in AD alleviation by microorganisms such as probiotics, flora transplantation, antimicrobial peptides, and so on, providing a new perspective for targeting microbiota to treat allergic skin inflammation.

Key words:atopic dermatitis;microbiota;“microbiota-skin-gut” axis;inflammation