Effect of gut microbiota on metabolism-associated fatty liver disease and research progress of exercise intervention

Abstract:

A large number of studies have demonstrated that gut microbiota is closely related to the occurrence and development of a variety of diseases such as neurodegenerative diseases and metabolic diseases. The species and number of bacteria are affected by genetic factors, dietary habits, exercise and other factors. In metabolism-associated fatty liver disease (MAFLD), some metabolites of gut microbiota promote the progression of the disease by increasing hepatic steatosis and changing intestinal mucosal permeability. The relationship between the changes in the species and number of bacteria and the progression of disease has also been extensively studied. However, the casual relationship between them remains unclear. Exercise can increase the species and number of beneficial gut microbiota and alleviate the gut microbiota disorders caused by high-fat diet to mitigate MAFLD. On the other side, gut microbiota can regulate the exercise capacity of the body. However, the mechanism of how exercise alleviates MAFLD through gut microbiota remains to be studied. This paper elaborates the important roles of gut microbiota and exercise in MAFLD by reviewing the relationship between the three.