Effect of microorganisms in intestinal tract and urinary system on the pathogenesis of renal calculus:a review

Abstract:

Renal calculus, a common urinary disorder in adults, influences the physiological function of the kidney and leads to urinary tract infection, thus threatening human health. Renal calculi are surrounded by a diversified microbial community, and the changes of microorganisms in the intestinal tract and urinary system may cause the occurrence and development of renal calculus. Particularly, Bifidobacterium, Lactobacillus, and Enterobacteriaceae are closely related to the occurrence of this disease. This review focused on the role of microorganisms in intestinal tract and urinary system in the formation of renal calculi. In addition, we also introduced the kidney-gut axis, influence of intestinal microorganisms on renal calculus from the production of short-chain fatty acids, the change of oxalate, and the occurrence of inflammation, and the prevention and treatment of this renal disease.