Molecular biological methods for improving the production of 1,3-propanediol by Klebsiella pneumonia：a review

Abstract:

1,3-propanediol (1,3-PD) can be used for chemical synthesis of a variety of compounds, including polyesters, polyethers and polyurethanes. Fermentation has great potential to improve 1,3-PD production. This study summarized the enzymes in the anaerobic metabolic pathways of Klebsiella pneumoniae and the catalysis, and reviewed the molecular modification of key enzymes in 1,3-PD production of K.pneumoniae, construction of genetically engineered strains and the expression of key enzyme genes, and knockout of by-product-related metabolic enzyme genes. Moreover, we also described the development prospects of 1,3-PD.