Research progress of the next-generation probiotics Akkermansia muciniphila

Abstract:

Akkermansia muciniphila, the next generation of probiotics with significant development potential, is widely considered to be a new candidate for alleviating diseases such as inflammatory bowel disease, irritable bowel syndrome, diabetes, obesity, and amyotrophic lateral sclerosis. With the increasing attention to intestinal bacteria and the advancement of omics technologies in recent years, A.muciniphila has rapidly become a hot spot in the research on probiotics. However, at present, the latest research progress of A.muciniphila remains to be summarized. Therefore, this paper summarizes the research achievements of A.muciniphila in the recent decade from the perspectives of the regulatory effect of A.muciniphila on host health, the isolation, identification, and culture of A.muciniphila, the challenges, opportunities, and prospects of research on A.muciniphila, aiming to provide reference for the further research and development of A.muciniphila.