Protective effect of Akkermansia muciniphila in diseases and the mechanisms

Abstract:

The intestinal symbiotic Akkermansia muciniphila comprises 1%–3% of gut microbiota, which induces T cell-dependent immune response during intestinal homeostasis. Thus, it may be involved in immune tolerance of normal gut. Experiments on disease and model animals have proven the vital role of this bacterial species in improving metabolic functions and immune response of the hosts, which has attracted the interests of scholars. Previous studies mainly focused on the correlation between A. muciniphila and diseases, but the mechanisms have not been systematically explored. This study aims to discuss the relationships of A. muciniphila with diseases in major human systems and immunity and the mechanisms, which is expected to provide evidence and routes for effective utilization of this bacterial species.

Key words:Akkermansia muciniphila;gut immune homeostasis;metabolic disease;neurological disease;cancer